COVID-19 Treatment Updates; Notable progress, medicines that can prevent patients from becoming severely infected; the facts | #coronavirus | #kids. | #children | #schools

3. FACT CHECK

[Antiviral Therapy – https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/

EXCERPT:

“Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication leads to many of the clinical manifestations of COVID-19. Antiviral therapies are being investigated for the treatment of COVID-19.

These drugs inhibit viral entry (via the angiotensin-converting enzyme 2 [ACE2] receptor and transmembrane serine protease 2 [TMPRSS2]), viral membrane fusion and endocytosis, or the activity of the SARS-CoV-2 3-chymotrypsin-like protease (3CLpro) and the RNA-dependent RNA polymerase.1 Because viral replication may be particularly active early in the course of COVID-19, antiviral therapy may have the greatest impact before the illness progresses into the hyperinflammatory state that can characterize the later stages of disease, including critical illness.2 For this reason, understanding the role of antivirals in treating mild, moderate, severe, and critical illness is necessary to optimize treatment for people with COVID-19. “]

4. Many Covid-19 patients die not just because of the virus but also due the patients own immune system responding In an exaggerated manner called *CYTOKINE STROM*. This stormy strong immune response not only kills the virus but also kills the patients. In February 2020 we didn’t know how to prevent it from happening. Now in June 2020, we know that *easily available medicines called Steroids,* that doctors around the world have been using for almost 80 years *can be used to prevent the cytokine storm in some patients*.

4. FACT CHECK:

https://www.covid19treatmentguidelines.nih.gov/immune-based-therapy/immunomodulators/corticosteroids/

EXCERPT: “Patients with severe COVID-19 can develop a systemic inflammatory response that can lead to lung injury and multisystem organ dysfunction. It has been proposed that the potent anti-inflammatory effects of corticosteroids might prevent or mitigate these deleterious effects.“

The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial, a multicenter, randomized, open-label trial in hospitalized patients with COVID-19, showed that the mortality rate was lower among patients who were randomized to receive dexamethasone than among those who received the standard of care.1

This benefit was observed in patients who required supplemental oxygen at enrollment. No benefit of dexamethasone was seen in patients who did not require supplemental oxygen at enrollment. Details of the RECOVERY trial are discussed in Clinical Data to Date below.1

1– RECOVERY Collaborative Group, Horby P, Lim WS, et al. Dexamethasone in hospitalized patients with COVID-19—preliminary report. N Engl J Med. 2020. Available at: https://www.ncbi.nlm.nih.gov/pubmed/32678530.

Clinical Trials LATEST INFORMATION: https://clinicaltrials.gov/ct2/results?cond=COVID-19&term=Corticosteroids&cntry=&state=&city=&dist=

EXCERPT: Several clinical trials to evaluate corticosteroids for the treatment of COVID-19 are currently underway or in development.

5. Now we also know that people with hypoxia became better just by making them lie down on their belly- known as prone position. Apart from this a few days ago Israeli scientists have discovered that a chemical known as Alpha Defensin produced by the patients White blood cells can cause the micro clots in blood vessels of the lungs and this could possibly be prevented by a drug called Cholcicine used over many decades in the treatment of Gout. So now we know for sure that patients have a better chance at surviving the COVID-19 infection now in June 2020 than in February 2020 for sure.

FACT Check: https://www.covid19treatmentguidelines.nih.gov/critical-care/

EXCERPT: For patients with persistent hypoxemia despite increasing supplemental oxygen requirements in whom endotracheal intubation is not otherwise indicated, the Panel recommends considering a trial of awake prone positioning to improve oxygenation (CIII).

The Panel recommends AGAINST using awake prone positioning as a rescue therapy for refractory hypoxemia to avoid intubation in patients who otherwise require intubation and mechanical ventilation (AIII).“

More here on Prone position: https://www.covid19treatmentguidelines.nih.gov/critical-care/oxygenation-and-ventilation/

Going forward there’s less need to panic about Covid-19 if we remember that a person who gets infected later has a better chance at survival than one who got infected early.

But its all on a case by case basis and no universal one fits all therapy is yet available. that may just be a vaccine.

Let’s all follow simple precautions like

  • 6 feet distancing from others -Wear proper masks –
  • Work from home whenever possible -Order delivery and take away of food groceries and vegetables
  • Stay at home during lockdown –
  • Hand wash & hygiene With this we can beat the virus .

If someone tells you every one is going to get infected, tell them that you are willing to and can afford to wait a bit longer… as each day passes we understand more about COVID infection.


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