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ALBANY, N.Y. (NEWS10) – An Albany Med scientist has received a grant to study the effects of menopause in Alzheimer’s disease. Women are disproportionately affected by the disease, making up two-thirds of the patient population. Hormonal changes during menopause can lead to obesity and pre diabetes, which are known risk factors for Alzheimer’s disease. Dr. Kristen Zuloaga’s research on mice will determine the effects of menopause on memory and look at whether increasing estrogen in the brain could reduce damage. 

“About 80% of those with Alzheimer’s disease have either pre-diabetes or type two diabetes. For our mice, we feed them a high fat diet that is equivalent to eating double bacon cheeseburgers for breakfast, lunch, and dinner and then we can look at the effects of this metabolic disease that we caused on the Alzheimer’s disease pathology in these mice and we can induce menopause,” said Dr. Zuloaga, an associate professor at Albany Medical College.



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